ZM223 是 NEDD8 活化酶 (NAE) 的抑制剂。
产品描述
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
体外活性
ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex[1].
Cas No.
2031177-48-5
分子式
C23H17F3N4O2S2
分子量
502.53
别名
ZM-223
储存和溶解度
DMSO:80 mg/mL (159.2 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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