Skp2 Inhibitor C1(SKPin C1)是Skp2介导p27降解的特异性抑制剂。

Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.

in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p< 0.0001) and a decrease in S phase (p< 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p< 0.0001) and an increase in G2-M phase (43%, p< 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels.

To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored.

432001-69-9

C18H13BrN2O4S2

465.34

SKPin C1

DMSO:6.4 mg/mL,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years