OTS514 是一种高效的TOPK抑制剂，IC50为 2.6 nM。它强效抑制 TOPK 阳性的肿瘤细胞生长，还可诱导细胞周期停滞和凋亡。

OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.

1338540-63-8

C21H20N2O2S

364.46

OTS 514;OTS514 HCl;OTS514 Hydrochloride;OTS-514

DMSO:90 mg/mL (246.94 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years