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SI-2 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SI-2 hydrochloride图片
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
SI-2 (EPH 116 hydrochloride) 是一种非常有前景的 SRC-3 抑制剂 (PPI),对乳腺癌细胞死亡的 IC50 值为 3-20 nM。 SI-2(EPH 116 盐酸盐)具有大大改善的毒性和药代动力学特征,具有可接受的口服可用性。
别名EPH 116 hydrochloride
Canonical SMILESCN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl
分子式C15H15N5.HCl
分子量301.78
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID:27084884