| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| 别名 | EPH 116 hydrochloride |
| Canonical SMILES | CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl |
| 分子式 | C15H15N5.HCl |
| 分子量 | 301.78 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available. Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID:27084884 |
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