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JZP 361
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JZP 361图片
CAS NO:1680193-80-9
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
JZP 361 是一种有效、可逆和选择性的人重组 MAGL (hMAGL) 抑制剂,IC50 为 46 nM。
Cas No.1680193-80-9
Canonical SMILESClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCN(C(N5C=NC=N5)=O)CC\4)=C1
分子式C22H20ClN5O
分子量405.88
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Patel et al (2015) Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 25 1436 PMID:25752982