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OB 24 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OB 24 hydrochloride图片
CAS NO:939825-12-4
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
OB 24 hydrochloride 是血红素加氧酶-1 (HO-1) 的有效抑制剂。血红素加氧酶 1 是热休克蛋白家族的成员,作为氧化应激的传感器和调节剂发挥着关键作用。 OB 24 hydrochloride 显着抑制体外细胞增殖和体内肿瘤生长和淋巴结/肺转移。 OB 24 hydrochloride 具有研究晚期前列腺癌 (PCA) 的潜力。
Cas No.939825-12-4
Canonical SMILESBrC1=CC=C(C=C1)CCC2(OCCO2)CN3C=CN=C3.Cl
分子式C15H17BrN2O2.HCl
分子量373.67
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol .

Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID:19808972