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PF-06260933
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06260933图片
CAS NO:1811510-56-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
PF6260933
PF 6260933
PF-6260933
产品介绍
PF6260933 是一种具有高度选择性及口服有活性的MAP4K4小分子抑制剂,在激酶实验中IC50为 3.7 nM,在细胞实验中IC50为 160 nM。

产品描述

PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.

体外活性

PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro.

体内活性

PF-06260933 treatment does not alter plasma lipid content in the mice model, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.

Cas No.

1811510-56-1

分子式

C16H13ClN4

分子量

296.76

别名

PF6260933;PF 6260933;PF-6260933

储存和溶解度

DMSO:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years