BI-78D3 是底物竞争性的JNK抑制剂(IC50:280 nM)，对 JNK 激酶活性具有抑制作用。

BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays >100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.

BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation[2].

In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes[1].

Cells are subjected to a dose range of doxorubicin concentrations in the presence or absence of a non-toxic dose (10 nM) of the small molecule JIP1-inhibitor BI-78D3. (Only for Reference)

883065-90-5

C13H9N5O5S2

379.37

Ethanol:1.9 mg/mL (5 mM)
DMSO:37.9 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years