Cornuside 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。 它通过下调MAPK和NF-κB信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。

1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.

131189-57-6

C24H30O14

542.49

Comuside;7-O-Galloylsecologanol;山茱萸新苷;7-Galloylsecologanol

DMSO:Soluble
Ethanol:Soluble
Pyridine, Methanol, etc.:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years