GW806742X 是ATP模拟物，是MLKL抑制剂，可结合 MLKL 假激酶结构域，Kd值为 9.3μM。它对VEGFR2的IC50为 2 nM，延缓 MLKL 膜移位并抑制坏死。

GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.

GW806742X (1 μM) retards MLKL translocation to the membrane.GW806742X (0.1-10000 nM) rescues 50% of wild-type mouse dermal fibroblasts (MDFs) from TSQ-induced necroptosis with an IC50< 50 nM when 1 ng/mL TNF is used.

579515-63-2

C25H22F3N7O4S

573.55

DMSO:125 mg/mL (217.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years