GW406108X 是一种 Kif15 抑制剂，在 ATPase 测定中的 IC50 为 0.82 uM。 它也是一种 ULK1 激酶抑制剂，pIC50 值为 6.37 (427?nM)，可阻断自噬通量。

GW108X is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW837331X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.

GW406108X were acting upon ULK1 and autophagy without affecting mTOR or AMPK activity as shown by monitoring ULK1 pS758 (mTOR site) or pS556 (AMPK site) levels[1].

1644443-92-4

C20H11Cl2NO4

400.21

GW108X

DMSO:45mg/ml(112.44mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years