FMK 9a 是一种不可逆的 ATG4B 抑制剂，在 TR-FRET 和基于细胞的 LRA 试验中 IC50 值为 80 和 73 nM。

FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.

FMK 9a forms a covalent bond with the more reactive thiol group of Cys74 located at the catalytic site of ATG4B thereby inactivating ATG4B proteolytic activity[1].

FMK 9a shows moderate solubility and high liver microsome clearances for human and mice of 13.9 and 70 mL/kg/min[1].

1955550-51-2

C23H21FN2O3

392.42

DMSO:150 mg/mL (382.24 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years