| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Canonical SMILES | [H][C@@]12CCN(C)C[C@]1([H])C1=CC(C)=CC=C1N2C(=O)CSC1=NN=NN1C1=CC=C(Cl)C=C1 |
| 分子式 | C22H23ClN6OS |
| 分子量 | 454.98 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Progesterone receptor membrane component 1 (Pgrmc1) ligand. Inhibits cell cycle progression and cell viability in cancer cell lines. Inhibits progesterone induced cytosolic Ca2+ increases in GnRH neurons in vitro. Ahmed et al (2010) Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. J.Pharmacol.Exp.Ther. 333 564 PMID:20164297 |Bashour and Wray (2012) Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1. Endocrinology. 153 4457 PMID:22822163 |Yoshitani et al (2005) A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: combination of in silico screening and surface plasmon resonance measurements. Proteomics. 5 1472 PMID:15798990 |
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