| CAS NO: | 2341840-98-8 |
| 包装: | 5mg |
| 市场价: | 5660元 |
Potent and selective BRD9 degrading PROTAC
| Cas No. | 2341840-98-8 |
| Canonical SMILES | COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C.Cl.Cl |
| 分子式 | C40H45N7O10.2HCl |
| 分子量 | 856.75 |
| 溶解度 | Water 17.14 mg/ml, DMSO 42.84 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PROTAC(R) composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . Potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. PROTAC(R) is a registered trademark of Arvinas Operations, Inc., and is used under license. Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID:28418626 |
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