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A 410099,1,amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A 410099,1,amine图片
CAS NO:2374122-37-7
包装:100mg
市场价:8232元

产品介绍
A 410099.1,胺是一种功能化的 IAP 配体,可用于合成 PROTAC,例如靶向 BTK 的 PROTAC(PROTAC 4 和 5)。
Cas No.2374122-37-7
Canonical SMILESC[C@@H](C(N[C@H](C(N1C[C@H](C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)N)=O)C4CCCCC4)=O)N(C(OC(C)(C)C)=O)C.Cl
分子式C32H49N5O5.HCl
分子量620.22
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Functionalized IAP ligand for PROTAC® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Tinworth et al (2019) PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 14 342 PMID:30807093