SMARCA-BD ligand 1 for Protac dihydrochloride

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CAS NO:

2369053-68-7

包装与价格：

产品介绍

SMARCA-BD ligand 1 for Protac dihydrochloride 是一种能够与 BAF ATPase 亚基 SMARCA2 结合的化合物，基于 PROTAC 技术，使 SMARCA2 降解。

Cas No.	2369053-68-7
Canonical SMILES	OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl.[H]Cl
分子式	C₁₄H₁₉Cl₂N₅O
分子量	344.24
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	SMARCA-BD ligand 1 for Protac dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1]. [1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.