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Safranal
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Safranal图片
CAS NO:116-26-7
包装:500mg
市场价:450元

产品介绍

Safranal是藏红花(Crocussativus)的主要成分,具有口服活性,是这种香料的独特香气来源。Safranal具有神经保护和抗炎作用,并有用于帕金森氏病的研究潜力。

Cas No.116-26-7
别名藏红花醛
Canonical SMILESO=CC1=C(C)C=CCC1(C)C
分子式C10H14O
分子量150.22
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml
储存条件Store at -20℃, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson's disease research[1].

Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs[1]. Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells[1]. Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells[1]. Western Blot Analysis[1] Cell Line: RAW264.7 cells and bone marrow-derived macrophages (BMDMs)

Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low[1]. Animal Model: Female BALB/c mice (18-20 g) (DSS-induced colitis mice)[1]

[1]. Peeraphong Lertnimitphun, et al. Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Front Pharmacol. 2019 Nov 1;10:1281.