Pantoprazole 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。

Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

PPZ(Pantoprazole) inhibits the proliferation of tumor cells, induces apoptosis and downregulates the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)[2]. Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells. Moreover, knockdown of TOPK in HCT 116 cells decreased their sensitivities to pantoprazole.

102625-70-7

C16H15F2N3O4S

383.37

泮托拉唑;SKF96022;BY1023

DMSO:71 mg/mL (185.2 mM)
H2O:<1 mgml
Ethanol:71 mg/mL (185.2 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years