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2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid图片
CAS NO:846549-37-9
包装与价格：
包装价格(元)
500mg电议
1g电议

产品介绍
2-((Azido-PEG8-carbamoyl)methoxy)aceticacid是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
Cas No.846549-37-9
别名O-(2-叠氮乙基)-O-[2-(二羟乙酰基-氨基)乙基]七聚乙二醇
Canonical SMILESO=C(O)COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O
分子式C22H42N4O12
分子量554.59
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562