Glafenine hydrochloride 是非甾体抗炎药, 可用于研究疼痛的缓解。

Glafenine Hydrochloride is an anti-inflammatory agent.

Glafenine increases the surface expression of mutant CFTR in baby hamster kidney (BHK) cells to 40% of that observed for wild-type CFTR[2]. Glafenine hydrochloride inhibits the proliferation and clonogenic activity of haSMCs and ECs in a dose-dependent manner. A block in the G2/M phase and a reduction in the G1 phase occurr. The migratory ability of haSMCs is impaired in a dose-dependent manner as well as the extracellular matrix protein tenascin is reduced[3].

Glafenine hydrochloride is added to the culture medium of the smooth muscle cells at three concentrations (10 μM, 50 μM, 100 μM). After 4 days of treatment, cells are harvested and the absolute cell number is counted[3].

65513-72-6

C19H18Cl2N2O4

409.26

Glafenin hydrochloride;格拉非宁盐酸盐

DMSO:60 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years