YHO-13351 free base 是 YHO-13177 的水溶性前药，YHO-13177 是 BCRP 的抑制剂。

YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP .

In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models[1].

912288-64-3

C26H33N3O4S

483.62

DMSO:90mg/mL (186.1mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years