Diclofensine 是一种高效单胺再摄取抑制剂，在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。

Diclofensine inhibits the uptake of serotonin, noradrenaline and dopamine.

A controlled trial with diclofensine, a new psychoactive drug, in the treatment of depression[1].

In a controlled study, out-patients suffering from moderate to severe depression were treated with the objective of assessing the new drug's therapeutically effective dose range. Maprotiline was used as a reference drug: fourteen patients were assigned to receive diclofensine and thirteen to receive maprotiline in a double-blind design. Depending on tolerance and efficacy, they were treated for periods ranging from 5 to 150 days. Doses were titrated to the optimum[1].

67165-56-4

C17H17Cl2NO

322.2

Ro 8-4650;(+/-)-双氮奋兴

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years