Elexacaftor 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR的加工和转运，增加细胞表面CFTR的数量。

Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.

Elexacaftor (VX-445) has the potential to treat cystic fibrosis and it also is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function. VX-445-Tezacaftor-VX-770 significantly improves Phe508del CFTR protein processing, trafficking, chloride transport. To a greater extent than any two of these agents in dual combination[2].

2216712-66-0

C26H34F3N7O4S

597.65

VX-445

DMSO:125 mg/mL (209.15 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years