Gap 26 是模拟肽，对应于连接蛋白 43 的残基 63-75，是间隙连接阻断剂。

Gap 26 is a mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

Oscillatory behaviour was abolished by Gap 26 at concentrations of 100-300 microM (IC50 of 20-30 microM), without a change in average tone. No synergy was evident between peptides corresponding to the extracellular loops, and cytoplasmic loop peptides were biologically inactive [1]. Photoliberating InsP(3) in a single cell within a confluent culture triggered an intercellular calcium wave, which was inhibited by the connexin mimetic peptide gap 26 [2].

197250-15-0

C70H107N19O19S

1550.8

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