Larazotide acetate 是合成肽，它起到紧密连接调节器的作用，并将泄漏连接反转到它们的常闭状态。

Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.

Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.

Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice.

881851-50-9

C34H59N9O12

785.89

H2O:16.67 mg/mL (21.21 mM),Need ultrasonic
DMSO:3.2 mg/mL (4.07 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years