Delavirdine mesylate 是一种口服活性非核苷逆转录酶抑制剂。它抑制 HIV-1 病毒复制，可以用于艾滋病的相关研究。它选择性地抑制 HIV-1 逆转录酶，其选择性超过 DNA 聚合酶 α?和 DNA聚合酶?δ 。

Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Delavirdine (mesylate) inhibits growth of clinical isolates of HIV-1 (ED50s =<0.005-0.69 μM). Delavirdine blocks replication of 25 primary HIV-1 isolates, including strains resistant to 3'-azido-2',3'-deoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean ED50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM)[1].

147221-93-0

C23H32N6O6S2

552.67

U 90152 (mesylate);BHAP-U 90152 (mesylate);Delavirdine (mesylate)

DMSO:40.3 mg/mL (72.92 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years