Velpatasvir是一种的 HCV NS5A 抑制剂。它也是SARS-CoV 3CLpro的抑制剂，IC50为 2.16 μM。

Velpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. GS-5816 has demonstrated pan-genotypic activity and a high barrier to resistance in HCV replicon assays. GS-5816 demonstrated pangenotypic antiviral activity in patients with genotype 1-4 HCV infection. It will be further evaluated in combination with other pangenotypic direct-acting antivirals to achieve the goal of developing a well-tolerated, highly effective treatment for all HCV genotypes.

1377049-84-7

C49H54N8O8

883.019

GS-5816;维帕他韦

DMSO:91 mg/mL(103.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years