Angiotensin II human是血管收缩剂，是肾素或血管紧张素系统的主要生物活性肽。它诱导血管平滑肌细胞生长，通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。它可调节人类血压，刺激交感神经，增加醛固酮生物合成和肾脏活动。

Angiotensin II is mediated by AT1 and AT2 receptors. AT1 and AT2 receptors have seven transmembrane glycoproteins with 30% sequence similarity.Angiotensin I convert Angiotensin II human through removing of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE).

Angiotensin II through being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions raises blood pressure (BP). Angiotensin II increased synthesis of collagen type I and III in fibroblasts, resulting in thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II also show actions such as induction of growth, cell migration, and mitosis of vascular smooth muscle cells. At the cellular level, responsiveness to Angiotensin II is converted by the expression of the two classes of angiotensin receptors (AT1 and AT2). Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, which increase blood pressure, the AT2 receptor contributes to the regulation of blood pressure and renal function.

Angiotensin II activates AT1 receptors causing hypertension in the kidney and promoting sodium reabsorption. To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, each animal is infused with Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks through Osmotic minipumps.

(129×C57BL/6) F1 mice, which lack AT1A receptors Angiotensin II used, are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 28 days of Angiotensin II infusion, hearts are harvested, weighed fixed in formalin, sectioned, and stained with Masson trichrome.

4474-91-3

C50H71N13O12

1046.197

Hypertensin II;血管紧张素Ⅱ;血管紧张素II;Angiotensin II;Ang II;DRVYIHPF

H2O:1 mg/mL
DMSO:5 mg/mL(4.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years