Eriodictyol chalcone 具有抗芳香化酶和抗 17β-HSD 的活性。它对恶性疟原虫的生长具有抗疟原虫作用。

Eriodictyol chalcone has anti-plasmodial effects on P. falciparum growth.

The orange-yellow colouration of Coreopsis grandiflora is mainly provided by the 6'-deoxychalcone butein and its 4'-glucoside respectively, as well as the corresponding 4-deoxyaurones sulfuretin and leptosidin (7-methoxysulfuretin) and their 6-glucosides. Incubation of butein or sulfuretin with enzyme preparations from petals of Coreopsis grandiflora in the presence of uridine 5'-diphosphoglucose led in each case to the formation of one single product, which was identified as butein 4'-glucoside and sulfuretin 6-glucoside, respectively. The 6'-deoxychalcone isoliquiritigenin was a poor substrate. Glucosylation of hydroxyl groups in other positions was not observed. Naringenin chalcone and Eriodictyol chalcone were not accepted as substrates. The glucosylation reaction of butein and sulfuretin exhibited an optimum at pH 8.0 and 7.0, respectively. Bivalent ions like Mg2+ and Ca2+ stimulated only slightly, whereas the addition of Cu2+, Zn2+, N-ethylmaleimide and p- hydroxymercuribenzoate led to a total loss of enzyme activity. The apparent Km values for butein and sulfuretin were 146 and 44 μM, respectively. CONCLUSIONS:The specific enzyme activity increased slowly during bud and flower development and declined in the later stages. The highest specific activity was observed in open flowers with 30 mm diameter. The rates of the glucosylation reaction with butein and sulfuretin had similar patterns.

14917-41-0

C15H12O6

288.25

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years