Dabigatran ethyl ester 是新型的口服抗凝化合物和凝血酶抑制剂。

Dabigatran ethyl ester is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.

Dabigatran etexilate was rapidly converted to Dabigatran, with peak plasma dabigatran concentrations being attained after approximately 1.5 h. there is a growing amount of clinical evidence which shows its safety and efficacy. Dabigatran may suppose a revolution in oral anticoagulation. The bioavailability of Dabigatran after p.o. administration of Dabigatran etexilate was 7.2%[1].

429658-95-7

C27H29N7O3

499.56

Dabigatran (ethyl ester)

H2O:1 mg/mL (2.00 mM),ultrasonic and warming and heat to 80°C
DMSO:1 mg/mL (2.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years