p-Hydroxycinnamic acid 是常见的食用酚，可抑制血小板活性，对血栓素 B2 和前列腺素 E2 的IC50值分别为 371 和 126 μM。

p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.

p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55?2 (SE 4?01) % and 35?6 (SE 2?35) % relative to the basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary hemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].

7400-08-0

C9H8O3

164.16

对羟基肉桂酸;NSC 59260;p-Hydroxy-cinnamic acid;p-Coumaric acid;p-Cumaric acid

DMSO:201 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years