TAPI-1 trifluoroacetat 是一种 ADAM17/TACE 抑制剂，可阻断细胞因子受体的脱落。

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.

TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells.

T4122

C28H38F3N5O7

613.62

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years