Aurantiamide acetate 是抑制口服有活性的CAThepsin选择性抑制剂，分离自Portulaca oleracea L。它具有抗炎作用，可用于研究炎性相关疾病。

Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].

Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively.

Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.

56121-42-7

C27H28N2O4

444.52

Asperglaucide;金色酰胺醇酯

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years