UNC2881 是一种特异性Mer激酶抑制剂，可抑制稳态的Mer激酶磷酸化，其IC50=22 nM。

UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.

在小鼠体内,UNC2881（94.5 ml/kg/min）的总清除率较高,口服生物利用率为14%.

UNC2881对697 B-ALL 细胞中Mer激酶活性有抑制作用（IC50：22 nM）,并抑制胶原刺激的血小板聚集。

1493764-08-1

C25H33N7O2

463.58

DMSO:85 mg/mL (183.4 mM)
H2O:<1 mgml
Ethanol:5 mg/mL (10.78 mM),warmed
Powder: -20°C for 3 years
In solvent: -80°C for 2 years