CE-245677 是可逆的Tie2和TrkA/B抑制剂，在细胞体系下的IC50值分别为 4.7 和 1 nM。

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM. Which displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].

In vivo rat, CE-245677 displays good oral absorption PK studies (F=80%)[1].

717899-97-3

C24H22Cl2N6O3

513.38

DMSO:125 mg/mL (243.48 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years