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DBCO-NHCO-PEG12-maleimide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DBCO-NHCO-PEG12-maleimide图片
包装:100mg
市场价:14400元

产品介绍
DBCO-NHCO-PEG12-maleimide是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
Canonical SMILESO=C(CCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)N2C3=CC=CC=C3C#CC4=CC=CC=C4C2
分子式C52H74N4O17
分子量1027.16
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.