PI4KIIIbeta-IN-10 是PI4KIIIβ抑制剂，IC50=3.6 nM。

PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).

The most potent of these molecules (PI4KIIIbeta-IN-10；compound 10) was screened over a panel of nine related lipid kinases and was >200 fold selective for PI4KIIIβ across all enzymes tested.?Two of the most potent and selective molecules (compound 9+10) were also the most effective antiviral compounds in a cellular model of Hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity.?PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and<20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ[1].

1881233-39-1

C22H25N3O5S2

475.58

DMSO:30 mg/mL (63.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years