BQR695 是一种磷脂酰肌醇 4-激酶抑制剂，对于人类和疟原虫 PI4KIIIβ 的IC50值分别为 80 和 3.5 nM。

BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines. Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function.

1513879-21-4

C19H20N4O3

352.394

BQR695;NVP-BQR695

DMSO:100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years