R-10015 是一种高效选择性LIMK抑制剂，通过结合 ATP 结合口袋阻断 LIMK，抑制人 LIMK1 的IC50值为 38 nM。它还是用于 HIV 感染的广谱抗病毒化合物。

R-10015 is a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket(IC50 of 38 nM for human LIMK1),and a broad-spectrum antiviral compound for HIV infection.

R10015 as a lead compound that blocks LIMK activity by binding to the ATP-binding pocket.?R10015 specifically blocks viral DNA synthesis, nuclear migration, and virion release.?In addition, R10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1), suggesting that LIMK inhibitors could be developed as a new class of broad-spectrum antiviral drugs.

2097938-51-5

C20H19ClN6O2

410.86

DMSO:62.5 mg/mL (152.12 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years