Aminopterin 是叶酸的 4-氨基衍生物，是叶酸拮抗剂，具有抗癌和免疫抑制活性，用于研究儿童白血病。它催化叶酸还原为四氢叶酸，竞争性抑制二氢叶酸还原酶，Ki值为 3.7 pM。

Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase

Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate is now more commonly used due to a more favorable therapeutic index[1]

54-62-6

C19H20N8O5

440.42

APGA;4-Aminofolic acid;氨基蝶呤

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years