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Amiselimod hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amiselimod hydrochloride图片
CAS NO:942398-84-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
MT-1303 hydrochloride
产品介绍
Amiselimod hydrochloride 是一种鞘氨醇 1-磷酸受体 1 (S1P1) 调节剂。

产品描述

Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.

体内活性

After oral administration of amiselimod or fingolimod at 1 mg/kg, the concentration of amiselimod-P in rat heart tissue was relatively lower than that of fingolimod-P, potentially contributing to the minimal cardiac effects of amiselimod. Amiselimod-P showed potent selectivity for S1P1, high selectivity for S1P5, minimal agonist activity for S1P4, no distinct agonist activity for S1P2 or S1P3, and approximately 5-fold weaker GIRK activation than fingolimod-P [1]. Amiselimod 0·2 mg and 0·4 mg significantly reduced the total number of gadolinium-enhanced T1-weighted lesions [2].

Cas No.

942398-84-7

分子式

C19H31ClF3NO3

分子量

413.9

别名

MT-1303 hydrochloride

储存和溶解度

DMSO:27mg/ml (65.23 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years