您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > INT-777
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
INT-777
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
INT-777图片
CAS NO:1199796-29-6
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品名称
S-EMCA
产品介绍

产品描述

INT-777 is a potent agonist of TGR5 (EC50: 0.82 μM).

体外活性

INT-777 has remarkable in vivo activity[1]. INT-777 effect on basal secretion is reduced in neuron-free and TTX-treated mucosal-submucosal preparations[3]. INT-777 (3 μM) enhances ATP production in the human enteroendocrine cell line NCI-H716 in a cAMP-dependent manner[2]. INT-777 (10 μM) lowers Isc and increases TEER when added on the serosal side of seromuscular stripped distal colon segments.

体内活性

INT-777 (1 μM/min/kg, p.o.) has an effective choleretic effect and prevents carboxyl CoA activation and subsequent conjugation, thereby favoring its cholehepatic shunt pathway with a ductular absorption and a potent choleretic effect in HF-fed TGR5-Tg male mice[1]. INT-777 (30 mg/kg/day, p.o.) enhances energy expenditure and decreases hepatic steatosis and obesity upon high-fat feeding in TGR5-Tg mice[2].

Cas No.

1199796-29-6

分子式

C27H46O5

分子量

450.65

别名

S-EMCA

储存和溶解度

DMSO:31 mg/mL (68.79 mM)
Ethanol:50 mg/mL (110.95 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years