Sparsentan 是一种具有高度选择的血管紧张素 II (Ki:0.8 nM)和内皮素 A 受体(Ki:9.3 nM)的双重拮抗剂。

Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)

254740-64-2

C32H40N4O5S

592.76

RE-021;DARA-a

DMSO:240 mg/mL (404.89 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years