Parmodulin 2 是一种蛋白酶激活受体 1 (PAR1) 变构抑制剂，IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂，可以抑制体外血小板聚集和体内血小板血栓形成。

ML 161 is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.

经P选择素表达测定,ML-161对凝血酶诱导的血小板活化具有抑制作用,该作用呈剂量依赖性。ML-161通过PAR1选择性抑制SFLLRN和凝血酶诱导的血小板聚集,但不影响AYPGKF,血栓素或ADP诱导的血小板聚集。

423735-93-7

C17H17BrN2O2

361.239

ML 161

DMSO:36.1 mg/mL (100 mM)
Ethanol:36.1 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years