PAR-2 Activating Peptide acetate(171436-38-7 free base) 是 Protease-activated Receptor-2 (PAR-2) 的激动剂。

PAR-2 Activating Peptide acetate is an agonist of Protease-Activated Receptor-2 (PAR-2).

Protease-Activated Receptor-2 Activating Peptide (SLIGRL-NH2) is an agonist of PAR-2 and MrgprC11[1]. Protease-Activated Receptor-2 Activating Peptide (SLIGRL-NH2) causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 μM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 μM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].

TP1046L

C31H60N10O9

716.88

PAR-2 Activating Peptide acetate(171436-38-7 free base);Protease-Activated Receptor-2 Activating Peptide acetate

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years