GLP-1R Agonist DMB是胰高血糖素样肽1受体的激动剂（GLP-1R；重组人受体的KB＝26.3nM）。

GLP-1R Agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R; KB = 26.3 nM for the recombinant human receptor).

GLP-1R Agonist DMB inhibits forskolin-induced cAMP accumulation in BHK cells expressing the recombinant human receptor with an EC50 value of 101 nM. GLP-1R Agonist DMB (100 and 1,000 nM) increases insulin levels induced by D-(+)-glucose in pancreatic islets isolated from wild-type, but not Glp1r knockout, mice[1].

GLP-1R Agonist DMB reduces fasting plasma glucose levels in mice when administered at a dose of 5 μmol/kg[1].

281209-71-0

C13H15Cl2N3O2S

348.25

DMSO:9mg/mL (25.8mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years