| CAS NO: | 69-81-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 电议 |
| 250mg | 电议 |
| Cas No. | 69-81-8 |
| 别名 | 卡巴克络；卡络柳钠 |
| Canonical SMILES | O=C1/C(C=C2C(O)CN(C)C2=C1)=N\NC(N)=O |
| 分子式 | C10H12N4O3 |
| 分子量 | 236.23 |
| 溶解度 | Water: 5 mg/mL (21.17 mM; ultrasonic and adjust pH to 12 with NaOH); DMSO:< 1 mg/mL (insoluble or slightly soluble) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1]. Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner[1].Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances[1]. Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2]. Animal Model: Male Sprague-Dawley rats weighing 180-230 g[2] [1]. Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. [2]. Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8. |
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