AF38469 是一种新型、特异性和可口服的Sortilin抑制剂，IC50值为 330 nM。

AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).

AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein.

1531634-31-7

C15H11F3N2O3

324.25

AF-38469

DMSO:40 mg/mL (123.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years