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Boc-NH-PEG2-CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Boc-NH-PEG2-CH2COOH图片
CAS NO:108466-89-3
包装:100mg
市场价:900元

产品介绍
Boc-NH-PEG2-CH2COOH是一种基于PEG合成的PROTAClinker,用于合成PROTAC。
Cas No.108466-89-3
别名2-[2-(叔丁氧羰基氨基)乙氧基]乙氧基乙酸
Canonical SMILESCC(C)(C)OC(NCCOCCOCC(O)=O)=O
分子式C11H21NO6
分子量263.29
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020 Feb 1;187:111952.