Plecanatide 是尿鸟苷蛋白的类似物,是一种可口服的鸟苷酸环化酶-C (GC-C) 受体激动剂。在 T84 细胞实验中,它激活 GC-C 受体以刺激 cGMP 合成的EC50值为 190 nM。在小鼠结肠炎模型中,它具有抗炎活性。
产品描述
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
体外活性
Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cyclic guanosine monophosphate (cGMP) synthesis in a dose-dependent manner with EC50?of 190 nM in T84 cells[2]
Cas No.
467426-54-6
分子式
C65H104N18O26S4
分子量
1681.89
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years